Effect of Different Orifice Diameter on The Flow Characteristic in Pressurized Metered Dose Inhaler by Using CFD

Muhammad Faqhrurrazi  Abd Rahman; Norzelawati  Asmuin; Nurul Fitriah  Nasir; Ishkrizat  Taib; Mohamad Nur Hidayat  Mat; Riyadhthusollehan  Khairulfuaad

Authors

Muhammad Faqhrurrazi Abd Rahman Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia
Norzelawati Asmuin Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia
Nurul Fitriah Nasir Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia
Ishkrizat Taib Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia
Mohamad Nur Hidayat Mat Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia
Riyadhthusollehan Khairulfuaad Department of Thermofluids Engineering, Faculty of Mechanical and Manufacturing Engineering, Universiti Tun Hussein Onn, 86400 Parit Raja, Johor, Malaysia

Keywords:

alveoli, orifice, pressurized metered dose inhalers, simulation

Abstract

Pressurized metered dose inhalers (pMDI) are portable, easy to use, convenient and these devices used multi-dose to administer aerosolized drug that use a propellant. A dose of medication actually is fixed and can be delivered with each actuation. There is a problem for this pMDI inhaler devices which is the particle do not reach into the alveolar. ANSYS Fluent Version 19.2 was used for parametric analysis to find the best orifice diameter. Standard K-epsilon was used as the turbulence model with enhanced wall treatment function. Discrete phase model was applied to represent the particle flow. The result shows that the best orifice diameter is 0.39mm that affect the highest particle velocity magnitude.