Synthesis and Characterization of Ionically Cross-Linked Chitosan Nanoparticles

Hemra Hamrayev; Kamyar Shameli

doi:10.37934/jrnn.7.1.713

Authors

Hemra Hamrayev Malaysia-Japan International Institute of Technology. Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100 Kuala Lumpur, Malaysia
Kamyar Shameli School of Medicine, Institute of Virology, Technical University of Munich, Munich Germany

DOI:

https://doi.org/10.37934/jrnn.7.1.713

Keywords:

Chitosan nanoparticles, tripolyphosphate, Biopolymer, Biodegradable compound, ionic-crosslinking

Abstract

Chitosan is an amino polysaccharide with exciting scientific uses because of its distinct structure and several various functions. High biocompatibility, strong biodegradability, and low toxicity are some of the chitosan's most notable characteristics. Chitosan holds great promise for biomedical uses including targeted delivery of drugs. Therefore, this research suggests tripolyphosphate (TPP)-based ionically cross-linked chitosan nanoparticles. XRD and FTIR analysis methods were used to characterize the acquired samples. The outcomes proved that chitosan nanoparticles have an XRD pattern similar to an amorphous polymer. Additionally, FTIR verified that the nanoparticles included chitosan ammonium groups linked to tripolyphosphoric groups of TPP.