Synthesis and Properties of Chitosan Nanoparticles CrossLinked with Tripolyphosphate

Mostafa Yusefi; Pooneh Kia; Siti Nur Amalina Mohamad Sukri; Roshafima Rasit Ali; Kamyar Shameli

doi:10.37934/jrnn.3.1.4652

Authors

Mostafa Yusefi Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia
Pooneh Kia Institute of Bio Science, University Putra Malaysia, Serdang 43400, Malaysia
Siti Nur Amalina Mohamad Sukri Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia
Roshafima Rasit Ali Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia
Kamyar Shameli Malaysia-Japan International Institute of Technology, Universiti Teknologi Malaysia, Jalan Sultan Yahya Petra, 54100, Kuala Lumpur, Malaysia

DOI:

https://doi.org/10.37934/jrnn.3.1.4652

Keywords:

Chitosan Nanoparticles, Sodium Tripolyphosphate, Cross-Linking, Facile Synthesis

Abstract

Chitosan nanoparticles (ChNPs) have been extensively examined for various biomedical applications due to their advantages include large surface area, biodegradability, and biocompatibility. The purpose of this research was to synthesize ChNPs using a simple ionic gelation technique by the interaction of low molecular weight chitosan (LMWC) and sodium tripolyphosphate (TPP) as a cross-linking agent. ChNPs, TPP, and LMWC were analysed by X-ray diffraction (XRD) and Fourier transforms infrared (FTIR) spectra that indicated the formation of ChNPs, attributing to the rearrangement of the nanoparticles after adding the TPP cross-linker into the LMWC solution. XRD analysis exhibited that ChNPs were amorphous, due to the effect of TPP cross-linker. Dynamic light scattering showed the nano-dimension of ChNPs with a hydrodynamic size of 68.50 nm. Thus, the obtained results indicated that the properties of chitosan were improved through converting it into nanoparticles using TPP initiated ionic gelation procedure.