Investigation of The Stability of The Lysozyme in Magnetic Particles for Drug Delivery

Abstract

This research investigated lysozyme stability in the presence of magnetic particles for drug delivery. Lysozyme can mostly be found in the hen egg albumin, and it also acts as an essential agent, which is antibodies to fight harmful bacteria or shield the human body. The problems in this research are magnetic particles that can cause toxicity and reduce the therapy's efficiency due to the degradation of carriers (drugs). To minimise this problem, the stability and activity of the lysozyme and Fe₂O₃ were investigated. The structure of lysozyme and Fe₂O₃ before and after adding acid or alkaline was defined, and the suitability of Fe₂O₃ as a drug delivery was determined. The stability of the lysozyme and Fe₂O₃was identified using an Ultraviolet-Visible (UV-Vis) Spectrophotometer, and the structure was investigated using a Field Emission Scanning Electron Microscope (FESEM) and Scanning Electron Microscope- Energy Dispersive X-Ray (SEM-EDX). Different concentrations become the parameters of this research as a comparison between the samples. This research found that the combination of the lysozyme alkaline material was suitable for the body at a pH of 12.2. It also found that Fe₂O₃ is ideal for drug delivery in the body when the lysozyme can be carried by Fe₂O₃ and dissolved in the Fe₂O₃.