Kinetic and Mechanism of Zerumbone Release from Cross-linked Gelatin-Zeolite Y Hybrid for Oral Anticancer Drug Delivery

Norashikin Salleh; Mohd Muzamir Mahat; Sabrina M. Yahaya; Rosmamuhamadani Ramli

doi:10.37934/armne.18.1.3243

Authors

Norashikin Salleh Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Mohd Muzamir Mahat Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Sabrina M. Yahaya Applied Chemistry Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Rosmamuhamadani Ramli Material Science and Technology Programme, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia

DOI:

https://doi.org/10.37934/armne.18.1.3243

Keywords:

Gelatin, zeolite Y, zerumbone, natural chemotherapy, oral controlled release

Abstract

A hybrid of zeolite Y-gelatin film as an oral dosage form for the natural anticancer drug was achieved by homogenously incorporating the drug-loaded zeolite Y into the gelatin solution. Drug ability was analyzed using computational and experimental approaches, drug encapsulation efficiency via the BET method, and possible interactions by FTIR analyses. Zerumbone released was done in both pH 1.2 and pH 7.4 mimicking the human gastrointestinal tract conditions for 24 hrs and subjected to kinetics study via suitable mathematical models to determine what governs the drug release with the results indicating that a sustained delivery of once-daily oral dosage form could be achieved.