Formulation and Characterization of Nanostructured Lipid Carrier Encapsulated Zingiber Zerumbet Oil using Ultrasonication Technique

R.  Hasham; N. A.  Rosli; A.  Abdul Aziz; R.  Aziz

Formulation and Characterization of Nanostructured Lipid Carrier Encapsulated Zingiber Zerumbet Oil using Ultrasonication Technique

Authors

R. Hasham Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia
N. A. Rosli Institute of BioproductInstitute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia Development, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia
A. Abdul Aziz Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia
R. Aziz Institute of Bioproduct Development, Universiti Teknologi Malaysia, 81310, Skudai, Johor, Malaysia

Keywords:

drug delivery, nanostructured lipid carrier, Zingiber zerumbet, nanoparticle, ultrasonication

Abstract

This study presents the formulation of nanostructured lipid carrier encapsulated Zingiber zerumbet oil (NLC-ZZ) using ultrasonication technique. NLC is the blend of solid lipid, liquid lipid and surfactant for encapsulation of poor water soluble actives. The NLC-ZZ formulation was characterized with respect to particle size, polydispersity index (PDI), zeta-potential, encapsulation efficiency and physical morphology. The NLC-ZZ formulation had an average diameter of 96.59 nm, PDI of 0.192, zeta-potential of -39.88 mV, and encapsulation efficiency of 90%, respectively. The NLC formulation for Zingiber zerumbet oil encapsulation has been successfully developed and is suitable for transdermal delivery system due to their nano-size and stability.

Downloads

PDF ³²

Published

2020-10-31

How to Cite

Hasham, R. ., Rosli, N. A. ., Abdul Aziz, A. ., & Aziz, R. . (2020). Formulation and Characterization of Nanostructured Lipid Carrier Encapsulated Zingiber Zerumbet Oil using Ultrasonication Technique. Journal of Advanced Research in Applied Mechanics, 11(1), 16–23. Retrieved from https://akademiabaru.com/submit/index.php/aram/article/view/1731