Reducing of Thrombosis in Mechanical Heart Valve through the Computational Method: A Review

Abstract

Thrombosis is formation of a blood clot, known as a thrombus within a blood vessel. This review paper discussed thrombosis which associated with the malfunction of the heart valve based on computational method to investigate the causes of blood clotting. The non-physiological flow is the causes of trapped platelet and the formation of blood clotting in the mechanical heart valve (MHV). Besides that, it is found that the hinge design, leaflet material and flow control can reduce blood clot formation. Furthermore, a specific method to reduce thrombosis through vortex generator design on the leaflet is also discussed. Finally, the review paper provides an important critical assessment regarding the method to reduce thrombosis in mechanical heart valve for engineers, mathematician, medical doctor and scientist.